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CAS RN: 51-60-5 | Product Number: N0447
Neostigmine Methyl Sulfate
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Purity: >98.0%(N)
Chemical Substance Law (ENCS):
9-708
Synonyms:
- (3-Dimethylcarbamoyloxyphenyl)trimethylammonium Methyl Sulfate
- (3-Hydroxyphenyl)trimethylammonium Methyl Sulfate Dimethylcarbamate
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
¥10,800
|
28 | It can be shipped from Saitama warehouse on the same day* | It can be shipped in about 2 weeks after ordering | |
| 25G |
¥32,300
|
9 | 5 | ≥40 |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
if you need further information.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | N0447 |
| Purity / Analysis Method | >98.0%(N) |
| Molecular Formula / Molecular Weight | C__1__3H__2__2N__2O__6S = 334.39 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 51-60-5 |
| Related CAS RN | 59-99-4 |
| Reaxys Registry Number | 3848275 |
| PubChem Substance ID | 87573782 |
| SDBS (AIST Spectral DB) | 4993 |
| Merck Index (14) | 6464 |
| MDL Number | MFCD00011796 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 144.0 to 148.0 °C |
| Solubility in Water | almost transparency |
Properties (reference)
| Melting Point | 146 °C |
| Solubility (soluble in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. H320 : Causes eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| Chemical Substance Law (ENCS) |
9-708 |
| RTECS# | CY1225000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | II |
Application
競合的な抗コリンエステラーゼ阻害剤
Neostigmine methyl sulfate, a synthetic physostigmine analog, is a competitive cholinesterase inhibitor. Unlike the plant alkaloid physostigmine [P0406], neostigmine methyl sulfate has a quaternary nitrogen, hence it more polar and does not cross the blood-brain barrier. Neostigmine methyl sulfate induces an increase in acetylcholine (ACh) in the synaptic cleft through reversible inhibition of its hydrolysis by acetylcholinesterase (AChE), and activates peripheral cholinergic nervous system. Neostigmine methyl sulfate used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as tubocurarine [C0433] (The product is for research purpose only.)
References
- The direct action of prostigmine on skeletal muscle; its relationship to the choline esters
- Studies on the safety of chronically administered intrathecal neostigmine methylsulfate in rats and dogs
- Acetylcholinesterase inhibitors: a patent review (2008 - present)
- LC/MS/MS analysis of quaternary ammonium drugs and herbicides in whole blood
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