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CAS RN: 73232-52-7 | Product Number: M3504
Methylnaltrexone Bromide
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Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- 17-(Cyclopropylmethyl)-3,14-dihydroxy-17-methyl-6-oxo-5α-4,5-epoxymorphinan-17-ium Bromide
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
¥23,000
|
15 | It can be shipped from Saitama warehouse on the same day* | It can be shipped in about 3-4 weeks after ordering |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | M3504 |
| Purity / Analysis Method | >95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__2__1H__2__6BrNO__4 = 436.35 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 73232-52-7 |
| Reaxys Registry Number | 8181088 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
Application
Methylnaltrexone Bromide: A Selective μ-Opioid Receptor Antagonist
Methylnaltrexone bromide is a selective antagonist of opioid binding at the μ-opioid receptor, a quaternary derivative of naltrexone [N1176]. As a quaternary amine, methylnaltrexone bromide has greater polarity and lower lipid solubility; therefore, it does not cross the blood-brain barrier.1,2) This allows methylnaltrexone bromide to act as a peripherally-acting μ-opioid receptor antagonist in tissues such as the gastrointestinal tract, thereby reducing the constipating effects of opioids without interfering with opioid-mediated analgesic effects on the central nervous system.3) (The product is for research purpose only.)
References
- 1) Receptor binding, antagonist, and withdrawal precipitating properties of opiate antagonists
- 2) Effects of opiate antagonists and their quaternary derivatives on heroin self-administration in the rat
- 3) Development of peripheral opioid antagonists: new insights into opioid effects (a review)
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