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CAS RN: 141505-33-1 | Product Number: L0320
Levosimendan
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Purity: >98.0%(HPLC)
Deleterious substance
Synonyms:
- (R)-Simendan
- 2-[2-[4-[(4R)-1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazinylidene]propanedinitrile
- OR-1259
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 50MG |
¥8,300
|
27 | It can be shipped from Saitama warehouse on the same day* | Contact Us | |
| 250MG |
¥25,000
|
1 | It can be shipped from Saitama warehouse on the same day* | 15 |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
if you need further information.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | L0320 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__1__2N__6O = 280.29 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 250MG-Glass Bottle with Plastic Insert (View image), 50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 141505-33-1 |
| Reaxys Registry Number | 6959885 |
| PubChem Substance ID | 468592148 |
| Merck Index (14) | 5471 |
| MDL Number | MFCD00867135 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | -600 to -650 deg(C=0.5, THF) |
Properties (reference)
| Melting Point | 205 °C |
| Specific Rotation | -627° (C=0.5,THF) |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P311 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
Related Laws:
| Poisonous or Deleterious | Deleterious substance |
| RTECS# | TY1570210 |
Transport Information:
| UN Number | UN3439 |
| Class | 6.1 |
| Packing Group | III |
Application
Levosimendan: A Calcium Sensitizer
Levosimendan, a calcium sensitizer, enhances the calcium sensitivity of contractile proteins by binding to cardiac troponin C.1) In addition, levosimendan has vasodilatory effects that are achieved by stimulation of ATP-dependent potassium channels in vascular smooth muscle, and also has the potential inhibitory effect of phosphodiesterase (PDE) III.2,3) Therefore, levosimendan is used in the treatment of acute and decompensated heart failure.4) (The product is for research purpose only.)
References
- 1)Cardiac Ca2+ Signaling and Ca2+ Sensitizers (a review)
- 2)Effects of Levosimendan, a Cardiotonic Agent Targeted to Troponin C, on Cardiac Function and on Phosphorylation and Ca2+ Sensitivity of Cardiac Myofibrils and Sarcoplasmic Reticulum in Guinea Pig Heart
- 3)Systemic and Coronary Hemodynamic Actions and Left Ventricular Functional Effects of Levosimendan in Conscious Dogs
- 4)Levosimendan (a review)
- 5)A strategy for high-throughput analysis of levosimendan and its metabolites in human plasma samples using sequential negative and positive ionization liquid chromatography/tandem mass spectrometric detection
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