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CAS RN: 153559-49-0 | Product Number: B4798
Bexarotene
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Purity: >96.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
¥21,800
|
≥60 | 6 | Contact Us |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
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* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | B4798 |
| Purity / Analysis Method | >96.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__4H__2__8O__2 = 348.49 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 153559-49-0 |
| Reaxys Registry Number | 7041961 |
| PubChem Substance ID | 354333139 |
| Merck Index (14) | 1194 |
| MDL Number | MFCD00932428 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Melting point | 220.0 to 225.0 °C |
Properties (reference)
| Melting Point | 222 °C |
| Maximum Absorption Wavelength | 264(MeOH) nm |
| Solubility (slightly sol. in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | DH6834830 |
Transport Information:
Application
Bexarotene: A Selective Retinoid X Receptor (RXR) Agonist
Retinoids are biological active analogs of vitamin A, which play essential roles in embryonic or adult cell behavior modulating cell proliferation, differentiation and apoptosis. Bexarotene, a synthetic retinoid known as LGD1069, selectively binds to and activates retinoid X receptors (RXRs). Thereby, bexarotene induces change in gene expression that lead to cell differentiation, decreased cell proliferation, apoptosis of some cancer cell types, and tumor regression. Recently, bexarotene has been reported that it acts to reduce harmful β-amyloid protein which has been suspected as a key contributor to Alzheimer’s disease. (The product is for research purpose only.)
References
- Chemoprevention of mammary carcinoma by LGD1069 (Targretin): an RXR-selective ligand
- Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists
- How retinoids regulate breast cancer cell proliferation and apoptosis (a review)
- Bexarotene: a promising anticancer agent (a review)
- ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in Alzheimer's disease Mouse Models
- Studies cast doubt on cancer drug as Alzheimer's treatment (News)
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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