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CAS RN: 53847-30-6 | Product Number: A3490
2-Arachidonoyl Glycerol (1% in Acetonitrile)
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Purity:
Deleterious substance
|Priority Assessment Chemical Substance
Synonyms:
- 2-AG (1% in Acetonitrile)
- 1,3-Dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoate (1% in Acetonitrile)
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
¥49,500
|
27 | It can be shipped from Saitama warehouse on the same day* | Contact Us |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
if you need further information.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | A3490 |
| Molecular Formula / Molecular Weight | C__2__3H__3__8O__4 = 378.55 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Frozen (-80°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 53847-30-6 |
Specifications
| Appearance | Colorless to Almost colorlessclear liquid |
| Concentration(HNMR) | 1.0 to 1.4 % |
| NMR | confirm to structure |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H311 : Toxic in contact with skin. H332 : Harmful if inhaled. H319 : Causes serious eye irritation. H370 : Causes damage to organs. H373 : May cause damage to organs through prolonged or repeated exposure. H225 : Highly flammable liquid and vapor. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P240 : Ground/bond container and receiving equipment. P210 : Keep away from heat/sparks/open flames/hot surfaces. No smoking. P233 : Keep container tightly closed. P243 : Take precautionary measures against static discharge. P241 : Use explosion-proof electrical/ ventilating/ lighting/ equipment. P242 : Use only non-sparking tools. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P403 + P235 : Store in a well-ventilated place. Keep cool. P405 : Store locked up. |
Related Laws:
| Chemical Substance Law (ENCS) | Priority Assessment Chemical Substance |
| Fire Defense Law | Group-4-1-II |
| Poisonous or Deleterious | Deleterious substance |
Transport Information:
| UN Number | UN1648 |
| Class | 3 |
| Packing Group | II |
Application
2-Arachidonylglycerol: An Endogenous Agonist of CB1 and CB2 Receptors
2-Arachidonylglycerol (2-AG) is an ester formed of arachidonic acid and glycerol, originally isolated from canine intestines.1) 2-AG an endocannabinoid that has been reported to act as an endogenous agonist of CB1 and CB2 receptors which are the primary molecular target responsible for the pharmacological effects of Δ9-tetrahydrocannabinol (THC), the psychoactive ingredient in Cannabis sativa. The endogenous cannabinoid system (ECS) is comprised of CB1 and CB2 receptors, and modulates neuronal and immune cell function, both of which play key roles in pain. Therefore, therapeutics targeting this system hold promise as novel analgesics.2-6) (The product is for research purpose only.)
References
- 1) Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
- 2) An Introduction to the Endogenous Cannabinoid System (a review)
- 3) Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites (a review)
- 4) Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders (a review)
- 5) 2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain (a review)
- 6) Recent advances in LC-MS/MS methods to determine endocannabinoids in biological samples: Application in neurodegenerative diseases (a review)
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