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CAS RN: 88495-63-0 | Product Number: A2191
Artesunate
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
¥5,400
|
2 | 15 | ≥40 | |
| 25G |
¥17,000
|
30 | 1 | Contact Us |
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | A2191 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__8O__8 = 384.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 88495-63-0 |
| Reaxys Registry Number | 6003212 |
| PubChem Substance ID | 87560999 |
| Merck Index (14) | 818 |
| MDL Number | MFCD00866204 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 132.0 to 137.0 °C |
| Specific rotation [a]20/D | +4.5 to +6.5 deg(C=1, CH2Cl2) |
Properties (reference)
| Melting Point | 133 °C |
| Specific Rotation | 5.5° (C=1,CH2Cl2) |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
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Application
Efflux pump inhibitor
References
- Artesunate enhances the antibacterial effect of β-lactam antibiotics against Escherichia coli by increasing antibiotic accumulation via inhibition of the multidrug efflux pump system AcrAB-TolC
Application
Artesunate: A Semi-Synthetic Derivative of Antimalaria Artemisinin
Artesunate is a semi-synthetic derivative of artemisinin [A2118] which is a biological active ingredient isolated from a traditional Chinese herbal medicine Artemisia annua. Artesunate is a prodrug that is rapidly converted to its active metabolite dihydroartemisinin [D3793]. Artesunate and its analogs have high efficacy against Plasmodium falciparum in the blood stages of the disease. The exact mechanism of action is still not clear, while the endoperoxide (O-O) subunit of the trioxane ring is critical for antimalarial activity. Several lines of evidence indicate that the O-O bond is easily broken by Fe2+, generating a number of reactive radicals oxidatively damage parasite. In addition, after 2000’s, the anti-tumor and antiviral activities of artesunate have been reported. (The product is for research purpose only.)
References
- Artesunate: A review of its pharmacology and therapeutic efficacy in the treatment of malaria
- Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration
- The antiviral activities of artemisinin and artesunate (a review)
- Artesunate Induces Oxidative DNA Damage, Sustained DNA Double-Strand Breaks, and the ATM/ATR Damage Response in Cancer Cells
- Stimulation of Suicidal Erythrocyte Death by Artesunate
- Development and validation of a high-performance liquid chromatography-mass spectroscopy assay for determination of artesunate and dihydroartemisinin in human plasma
PubMed Literature
Articles/Brochures
TCIMAIL
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Safety Data Sheet (SDS)
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Specifications
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