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Published TCIMAIL newest issue No.197
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CAS RN: 1101854-58-3 | Product Number: J0038
JZL 184
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Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- 4-Nitrophenyl 4-[Bis[benzo[d][1,3]dioxol-5-yl](hydroxy)methyl]piperidine-1-carboxylate
- 4-Nitrophenyl 4-[Bis(1,3-benzodioxol-5-yl)(hydroxy)methyl]-1-piperidinecarboxylate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
190,00 €
|
Contact Us | 18 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | J0038 |
| Purity / Analysis Method | >95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__2__7H__2__4N__2O__9 = 520.49 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 1101854-58-3 |
| Reaxys Registry Number | 20284487 |
| MDL Number | MFCD11976911 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| Melting point | 127.0 to 131.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 129 °C |
GHS
Related Laws:
| RTECS# | TM6127800 |
Transport Information:
| HS Number | 2934999090 |
Application
JZL 184: A Potent and Selective Inhibitor of Monoacylglycerol Lipase (MAGL)
Endogenous cannabinoids, such as anandamide [A3448] and 2-arachidonoyl glycerol (2-AG) [A3490], are biologically active lipids that activate the cannabinoid receptors CB1 and CB2. Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system (ECS) which is involved in a variety of physiological processes. Endocannabinoid signaling is terminated by enzymatic hydrolysis, a process that for anandamide is mediated by fatty acid amide hydrolase (FAAH), and for 2-AG is thought to involve monoacylglycerol lipase (MAGL). JZL 184 is a potent and selective inhibitor of MAGL and has been reported to raise mice brain 2-AG levels by eight-fold without altering anandamide and to attenuate neuropathic pain. (The product is for research purpose only.)
References
- Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
- Characterization of Monoacylglycerol Lipase Inhibition Reveals Differences in Central and Peripheral Endocannabinoid Metabolism
- Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain
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