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AMP-Activated Protein Kinase (AMPK) Activator
5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR, 1) selectively activates AMP-activated protein kinase (AMPK).1) Adamo et al. reported that 1 induces the expression of Klf2 and Klf4 and activates the pluripotency transcriptional network in mouse embryonic stem cells (mESCs).2) In mouse embryonic fibroblasts (MEFs), 1 induces Klf4, Klf2, and Myc upregulation. As shown in Table, 1 antagonizes retinoic acid induced differentiation in mESCs.
Table. Effects of AICAR on the pluripotency transcriptional network in the presence of high doses of retinoic acid.2)
References
- 1) 5-Aminoimidazole-4-Carboxamide Ribonucleoside
A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells? - 2) AICAR activates the pluripotency transcriptional network in embryonic stem cells and induces KLF4 and KLF2 expression in fibroblasts
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