It has come to our notice that certain fraudulent individuals or entities are misusing our Company’s name and TCI’s registered trademarks by promoting and offering regulated and hazardous chemical substances through online platforms like YouTube. We hereby categorically clarify that TCI has no association or connection whatsoever with the products being displayed or sold in the videos. These products have been falsely represented as being associated with TCI, and the unauthorized use of our trademark and brand name is both illegal and misleading. TCI Chemicals markets and sells its products exclusively through its official website and authorized distributors. If you become aware of any such fraudulent activity or require clarification, you may reach out to us at: Sales-IN@TCIchemicals.com. Click Here to View the Caution Notice.
Product Document Searching Made Easy by 2D Code! | [Product Highlights] Endogenous Biotin-Blocking Reagent...Maximum quantity allowed is 999
Please select the quantity
MAC-TBS Reagent Usable for Three Component Coupling Reactions
(tert-Butyldimethylsilyloxy)malononitrile (1), developed by Nemoto et al., is called a MAC (Masked Acyl Cyanide) reagent.1) 1 forms an anion species 2 by the treatment of a base and 2 acts as an acyl anion equivalent. By taking advantage of this property, 1 can be applied to three component coupling reactions with electrophiles and nucleophiles.2,3) For example, 2 reacts with aldehydes to form an acyl cyanide intermediate 3. Sequential addition of amines as nucleophiles gives α-siloxyamides as three component adducts.3) In these sequential steps, three components can be added in one-portion to the flask. This reaction can be applied to electrophiles such as aldehydes, ketones and imines and nucleophiles such as alcohols and amines. Furthermore, this reaction can afford Weinreb amides when using DMHA·HCl.
Related Products
References
- 1)Development of a new acyl anion equivalent for the preparation of masked activated esters, and their use to prepare a dipeptide
- 2)A New One-Pot Method for the Synthesis of α-Siloxyamides from Aldehydes or Ketones and Its Application to the Synthesis of (−)-Bestatin
- 3)Direct One-Pot Synthesis of α-Siloxy-Weinreb Amides from Aldehydes