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CAS RN: 83141-10-0 | Product Number: D5138
2,6-Difluoro-3-nitrobenzoic Acid
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Purity: >98.0%(GC)(T)
Synonyms:
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
₹3,760.00
|
Contact Us | 2 |
|
| 25G |
₹16,240.00
|
Contact Us | 18 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | D5138 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__7H__3F__2NO__4 = 203.10 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 83141-10-0 |
| Reaxys Registry Number | 4868029 |
| PubChem Substance ID | 468591296 |
| MDL Number | MFCD00119291 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 99.0 to 103.0 °C |
Properties (reference)
| Melting Point | 103 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
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Application
A Synthetic Intermediate of B-Raf Kinase Inhibitors and Fluoroquinolone Antibiotics
This product is used for the synthesis of B-Raf kinase inhibitors such as vemurafenib causes programmed cell death (apoptosis) in melanoma cell lines. 1,2) In addition, it is also used for the synthesis of fluoroquinolone antimicrobial agents. 3)
References
- 1) Pyrazolopyridine Inhibitors of B-RafV600E. Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors
- 2) Pyrazolopyridine inhibitors of B-RafV600E. Part 2: Structure-activity relationships
- 3) A Novel Antibacterial 8-Chloroquinolone with a Distorted Orientation of the N1-(5-Amino-2,4-difluorophenyl) Group
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