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CAS RN: 252917-06-9 | Product Number: C2943
CHIR 99021
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Purity: >97.0%(HPLC)
Synonyms:
- 6-[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
₹8,000.00
|
Contact Us | 34 |
|
| 100MG |
₹24,600.00
|
Contact Us | 16 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | C2943 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__1__8Cl__2N__8 = 465.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 252917-06-9 |
| Reaxys Registry Number | 25763160 |
| PubChem Substance ID | 468591053 |
| MDL Number | MFCD11846251 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
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Application
Research on regenerative medicine
CHIR 99021 is also used with XAV 939 as a key component for mouse epiblast stem cell and human embryonic stem cell self-renewal.1) Under cytokine-free conditions, the combination of CHIR 99021 and the mTOR inhibitor, rapamycin, maintains mouse and human hematopoietic stem cells.2) In the presence of CHIR 99021, OCT4-transduced human blood CD34+ cells are converted into induced mesenchymal stem cells (iMSCs).3)
References
- 1) Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal
- 2) Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways
- 3) Rapid and efficient reprogramming of human fetal and adult blood CD34+ cells into mesenchymal stem cells with a single factor
Application
CHIR 99021: A Specific Glycogen Synthase Kinase 3 (GSK3) Inhibitor
CHIR 99021 is a specific glycogen synthase kinase 3 (GSK3) inhibitor. GSK3 is a serine/threonine kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues, and that plays a key role in both the insulin and Wnt signaling pathways.1,2) CHIR 99021 specifically inhibits the GSK3 pathway.3,4)
References
- 1) Inactivation of glycogen synthase kinase-3β by phosphorylation: new kinase connections in insulin and growth-factor signalling
- 2) WNT-1 and HGF Regulate GSK3β Activity and β-Catenin Signaling in Mammary Epithelial Cells
- 3) Regulation of Wnt signaling during adipogenesis
- 4) Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors
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