Caution Notice:
It has come to our notice that certain fraudulent individuals or entities are misusing our Company’s name and TCI’s registered trademarks by promoting and offering for sale regulated and hazardous chemical substances, including Potassium Cyanide, through online platforms like YouTube. We hereby categorically clarify that TCI has no association or connection whatsoever with the products being displayed or sold in these or similar videos. These products have been falsely represented as being associated with TCI, and the unauthorized use of our trademark and brand name is both illegal and misleading. TCI Chemicals is a responsible global organization committed to adhering to all applicable international and domestic regulatory frameworks. We do not manufacture, distribute, or engage in the sale of regulated chemical substances in India or in any other jurisdiction unless specifically authorized by the relevant laws and regulatory agencies. All our operations and offerings are governed by stringent safety, quality, and compliance protocols in accordance with applicable laws. Further, TCI Chemicals markets and sells its products exclusively through its official website and authorized distributors. We do not sell, endorse, or supply our products through any third-party platforms, unauthorized agents, or resellers. Any individual or organization purchasing products outside these official channels does so at their own risk, and TCI disclaims all responsibility and liability for any consequences arising therefrom. Members of the public, customers, and partners are strongly advised to exercise caution and conduct due diligence before engaging in any transactions involving products claiming association with TCI Chemicals. The official list of our authorized distributors is publicly available and may be accessed at: https://www.tcichemicals.com/IN/en/distributor/index. We are currently pursuing appropriate legal remedies against those misusing our brand, and we reserve all rights available to us under applicable intellectual property and criminal laws. If you become aware of any such fraudulent activity or require clarification, you may reach out to us at: Sales-IN@TCIchemicals.com. Your vigilance and cooperation are essential in safeguarding the public interest and protecting the integrity of the TCI brand.
Maximum quantity allowed is 999
GSK-3 Inhibitor
1
CHIR 99021 (1) is a cell-permeable and highly selective GSK-3 inhibitor1) and inhibits GSK3α (IC50=10 nM) and GSK3β (6.7 nM).2) 1 is also used as a key component for mouse embryonic stem cell self-renewal.3) Under cytokine-free conditions, the combination of 1 and the mTOR inhibitor, rapamycin, maintains mouse and human hematopoietic stem cells.4) In the presence of 1, OCT4-transduced human blood CD34+ cells are converted into induced mesenchymal stem cells (iMSCs).5)
The product is for research purposes only.
References
- 1) The selectivity of protein kinase inhibitors: further update
- 2) Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo
- 3) Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal
- 4) Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways
- 5) Rapid and efficient reprogramming of human fetal and adult blood CD34+ cells into mesenchymal stem cells with a single factor
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