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CAS RN: 105628-07-7 | Product Number: F0839
Fasudil Hydrochloride
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Purity: >96.0%(HPLC)(qNMR)
Synonyms:
- 1-(5-Isoquinolinesulfonyl)homopiperazine Hydrochloride
- 5-(1-Homopiperazinyl)sulfonylisoquinoline Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 100MG |
€81.00
|
1 | ≥100 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | F0839 |
| Purity / Analysis Method | >96.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__1__4H__1__7N__3O__2S·HCl = 327.83 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 105628-07-7 |
| Related CAS RN | 186694-02-0&103745-39-7 |
| Reaxys Registry Number | 5466340 |
| PubChem Substance ID | 160871255 |
| Merck Index (14) | 3942 |
| MDL Number | MFCD00943198 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Purity(qNMR) | min. 96.0 % |
Properties (reference)
| Melting Point | 222 °C(dec.) |
| Solubility in water | Soluble |
| Solubility (soluble in) | Methanol |
| Solubility (insoluble in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | HM4033500 |
Transport Information:
| HS Number | 2935909099 |
Application
Protein Kinase Inhibitor
References
- 1)Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C
- 2)Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells
- 3)Specificity and mechanism of action of some commonly used protein kinase inhibitors
- 4)Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture
- 5)Neurotrophins mediate human embryonic stem cell survival
- 6)A ROCK inhibitor permits survival of dissociated human embryonic stem cells
Application
Fasudil Hydrochloride: A Rho Kinase Inhibitor
Fasudil hydrochloride (HA-1077) is a prodrug of hydroxyfasudil [H1745 (HCl salt)], which is a potent and selective Rho kinase (a protein phosphatase) inhibitor. Hydroxyfasudil inhibits phosphorylation of myosin light chain, the final step in the vascular smooth muscle contractile mechanism, by inhibiting Rho kinase. Fasudil has been used as a vasodilator for the treatment of cerebral vasospasm. (The product is for research purpose only.)
References
- Pharmacological profile of hydroxyfasudil as a selective rho kinase inhibitor on ischemic brain damage
- Hydroxyfasudil, and active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase
- Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells
- Rho kinase (ROCK) inhibitors (a review)
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