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CAS RN: 155558-32-0 | Product Number: H1745
Hydroxyfasudil Hydrochloride
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Purity: >98.0%(HPLC)
Synonyms:
- 5-[(1,4-Diazepan-1-yl)sulfonyl]isoquinolin-1(2H)-one Hydrochloride
- HA 1100 Hydrochloride
- 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine Hydrochloride
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 10MG |
$190.00
|
Contact Us | Contact Us | 15 |
|
| 50MG |
$569.00
|
Contact Us | 2 | 16 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | H1745 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__1__7N__3O__3S·HCl = 343.83 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 155558-32-0 |
| PubChem Substance ID | 468592024 |
| MDL Number | MFCD06411567 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Water | max. 7.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 299 °C(dec.) |
GHS
Related Laws:
Transport Information:
| HS Number | 2933.99.9701 |
Application
Hydroxyfasudil Hydrochloride: An Active Metabolite of Fasudil, a Rho Kinase Inhibitor
Hydroxyfasudil hydrochloride is an active metabolite of fasudil [F0839 (HCl salt)], which is a potent and selective Rho kinase (a protein phosphatase) inhibitor. Hydroxyfasudil inhibits phosphorylation of myosin light chain, the final step in the vascular smooth muscle contractile mechanism, by inhibiting Rho kinase. Fasudil has been used as a vasodilator for the treatment of cerebral vasospasm. (The product is for research purpose only.)
References
- Pharmacological profile of hydroxyfasudil as a selective rho kinase inhibitor on ischemic brain damage
- Hydroxyfasudil, and active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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