Tankyrase Inhibitor

References

• 1)Tankyrase inhibition stabilizes axin and antagonizes Wnt signaling
  • S.-M. A. Huang, Y. M. Mishina, S. Liu, A. Cheung, F. Stegmeier, G. A. Michaud, O. Charlat, E. Wiellette, Y. Zhang, S. Wiessner, M. Hild, X. Shi, C. J. Wilson, C. Mickanin, V. Myer, A. Fazal, R. Tomlinson, F. Serluca, W. Shao, H. Cheng, M. Shultz, C. Rau, M. Schirle, J. Schlegl, S. Ghidelli, S. Fawell, C. Lu, D. Curtis, M. W. Kirschner, C. Lengauer, P. M. Finan, J. A. Tallarico, T. Bouwmeester, J. A. Porter, A. Bauer, F. Cong, Nature 2009, 461, 614.
• 2)β-Catenin in pluripotency: Adhering to self-renewal or wnting to differentiate?
  • G. S. Sineva, V. A. Pospelov, Int. Rev. Cell Mol. Biol. 2014, 312, 53.
• 3)β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4
  • K. C. Davidson, A. M. Adams, J. M. Goodson, C. E. McDonald, J. C. Potter, J. D. Berndt, T. L. Biechele, R. J. Taylor, R. T. Moon, Proc. Natl. Acad. Sci. USA 2012, 109, 4485.
• 4)Successful reprogramming of epiblast stem cells by blocking nuclear localization of β-catenin
  • H. Murayama, H. Masaki, H. Sato, T. Hayama, T. Yamaguchi, H. Nakauchi, Stem Cell Rep. 2015, 4, 103.
• 5)Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling
  • H. Wang, J. Hao, C. C. Hong, ACS Chem. Biol. 2011, 6, 192.
• 6)Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm
  • E. Willems, S. Spiering, H. Davidovics, M. Lanier, Z. Xia, M. Dawson, J. Cashman, M. Mercola, Circ. Res. 2011, 109, 360.

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