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5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB, 1) is a selective inhibitor of transcription elongation by RNA polymerase II, further inhibiting mRNA synthesis in eukaryotic cells.1) The inhibition can trigger p53-dependent apotosis of tumor cells.2) DRB can also inhibit HIV transcription by targeting elongation enhanced by the HIV-encoded transactivator (Tat)3).
References
1)Selective inhibitation of transcription elongation
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