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Published TCIMAIL newest issue No.197
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MEK Inhibitor
No.163(October 2014)
The homeodomain protein Nanog plays an essential role in the self-renewal of embryonic stem (ES) cells.1-3) On the other hand, it was reported that Nanog gene repression was primarily mediated by the Grb2/Mek pathway.4) 2-(2-Amino-3-methoxyphenyl)chromone (PD 98059, 1) is a MAPK/ERK kinase (MEK) inhibitor5,6) and used as one of the biologically active small molecules in the study described above.4)
Grb2: growth factor receptor-bound protein 2
MAPK: mitogen-activated protein kinase
ERK: extracellular signal-regulated kinase
MAPK: mitogen-activated protein kinase
ERK: extracellular signal-regulated kinase
References
- 1)The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells
- 2)Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells
- 3)Nanog is the gateway to the pluripotent ground state
- 4)The Grb2/Mek pathway represses Nanog in murine embryonic stem cells
- 5)A synthetic inhibitor of the mitogen-activated protein kinase cascade
- 6)PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
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