Antiviral Reagent Causing Mutations during Viral Replication by RNA-Dependent RNA Polymerase

RNA-dependent RNA polymerase (RdRp) is an essential enzyme for replication processes of RNA viruses such as SARS-CoV and MERS-CoV. Therefore, RdRp is one of the important targets for antiviral activity research. N⁴-Hydroxycytidine is an antiviral targeting RNA replication by RdRp. N⁴-Hydroxycytidine is transformed into its active form, N⁴-hydroxycitidine triphosphate, in host cells, resulting in viral error catastrophe and inhibiting viral replication by incorporation into the viral genome.^1,2)

Related Products

H1803

N⁴-Hydroxycytidine

F1296

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D4823

PSI-6206

References

• 1) β-D-N⁴-Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome
  • N. Urakova, V. Kuznetsova, D. K. Crossman, A. Sokratian, D. B. Guthrie, A. A. Kolykhalov, M. A. Lockwood, M. G. Natchus, M. R. Crowley, G. R. Painter, E. I. Frolova, I. Frolov, J. Virol. 2018, 92, e01965-17.
• 2) Small-Molecule Antiviral β-D-N⁴-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance
  • M. L. Agostini, A. J. Pruijssers, J. D. Chappell, J. Gribble, X. Lu, E. L. Andres, G. R. Bluemling, M. A. Lockwood, T. P. Sheahan, A. C. Sims, M. G. Natchus, M. Saindane, A. A. Kolykhalov, G. R. Painter, R. S. Baric, M. R. Denison, J. Virol. 2019, 93, e01348-19.

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