Published TCIMAIL newest issue No.196
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Chemical Synthesis of the Glycosaminoglycans
Glycosaminoglycans (GAG) are large molecule polysaccharides (molecular weight: roughly 10,000 - 2 million) constructed with a number of disaccharide repeating units consisting of a uronic acid (-glucuronic acid or -iduronic acid) and a hexosamine (N-acetylgalactosamine or N-acetylglucosamine). Most of the GAG sugar chains have sulfate groups. The number of repeating units and sulfate groups plays an important role for the biological activities of GAG. It is actually known that various functions of life phenomena are promoted by gaining a diversity of structure through GAG.
Since TCI has advanced, proprietary technology for synthesis of a wide range of sugar chains, it is possible to synthesize GAG having sulfate groups at a desired position and being composed of required sugar residues with high purity and large scale. Please contact us when you require GAG sugar chains.
See Glycosaminoglycans (GAG) Product Category Page
See Oligosaccharide Custom Synthesis Page
Anti-Glycosaminoglycan Antibodies
The extracellular matrix (ECM) is an essential element for higher organisms to form cells, tissues, and organs; to control cell-cell connections and functions. The ECM also greatly affects several biological phenomena (such as development, aging, inflammation, wound healing, and immunity). Glycosaminoglycans (GAG), such as chondroitin sulfate, hyaluronic acid and keratan sulfate, are major components of the ECM and play an important role. Analysis of glycosaminoglycans is very difficult, especially when performing in situ analysis of cells and tissues. Thus, antibodies are particularly important as a detection tool.
- A2968
- Anti-Keratan Sulfate Monoclonal Antibody (R-10G)
- A2872
- Anti-Chondroitin Sulfate D Monoclonal Antibody (MO-225)
- A3143
- Anti-Chondroitin Sulfate A Monoclonal Antibody (LY111)
- A3342
- Anti-Perlecan Monoclonal Antibody (HK-102)
- A3251
- Anti-6-sulfo LacNAc Monoclonal Antibody (AG105)
- A3252
- Anti-6,6'-disulfo LacNAc Monoclonal Antibody (L4L4-8)
- A3253
- Anti-Sialyl 6,6'-disulfo LacNAc Monoclonal Antibody (G270-16)
Anti-chondroitin sulfate antibody can be utilized for detection of the chondroitin sulfate A or D
These chondroitin sulfate were coated on ELISA plate. These antigens and anti-chondroitin sulfate antibodies were reacted at appropriate time, then 1st antibodies were detected using appropriate secondary antibodies.
Sulfated Hyaluronic Acids
Sulfated hyaluronic acid is known to stabilize growth factors, such as FGF1 and FGF2. As a result it is expected to be used as a substitute for sulfated polysaccharides in the context of regenerative medicine as well as in several other fields where sulfated polysaccharides may be needed.
TCI offers sulfated hyaluronic acid with various sulfation degree that can be modified by changing the synthetic reaction.