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Published TCIMAIL newest issue No.197
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CAS RN: 139180-30-6 | Product Number: Z0042
ZM 241385
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Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- 4-[2-[[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethyl]phenol
- 4-[2-[[7-Amino-2-(2-furyl)[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethyl]phenol
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
€192.00
|
Contact Us | 39 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | Z0042 |
| Purity / Analysis Method | >95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__1__6H__1__5N__7O__2 = 337.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 139180-30-6 |
| Reaxys Registry Number | 8162461 |
| MDL Number | MFCD00908394 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| Melting point | 225.0 to 229.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 227 °C |
GHS
Related Laws:
| RTECS# | SJ6064000 |
Transport Information:
| HS Number | 2934999090 |
Application
ZM 241385: A Potent A2A Adenosine Receptor (A2AR) Antagonist
The A2A adenosine receptor (A2AR) is a G protein-coupled receptor (GPCR) belonging to the P1/adenosine receptor (AR) family, which also includes the A1, A2B and A3 receptor subtypes. ARs play a central role in a wide range of physiological processes, including sleep regulation, angiogenesis and modulation of the immune system.1,2) A2AR has been reported to play a role in the regulation of myocardial coronary blood flow, sleep regulation, angiogenesis and immunosuppression. Thus, ZM 241385 is a potent A2AR antagonist and has been used as a tool in many pharmacological studies.2-4) (The product is for research purpose only.)
References
- Human Adenosine A2A Receptor: Molecular Mechanism of Ligand Binding and Activation (a review)
- The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist
- The in vitro pharmacology of ZM 241385, a potent, non-xanthine, A2A selective adenosine receptor antagonist
- Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors
Product Documents (Note: Some products will not have analytical charts available.)
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