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Published TCIMAIL newest issue No.197
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CAS RN: 175865-59-5 | Product Number: V0158
Valganciclovir Hydrochloride
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Purity: >98.0%(T)
Synonyms:
- L-Valine 2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl Ester Monohydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 250MG |
€39.00
|
1 | 29 |
|
| 1G |
€106.00
|
1 | 21 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | V0158 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__1__4H__2__2N__6O__5·HCl = 390.83 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 175865-59-5 |
| Reaxys Registry Number | 15558307 |
| PubChem Substance ID | 468593105 |
| Merck Index (14) | 9907 |
| MDL Number | MFCD08460118 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(Argentometric Titration) | min. 98.0 %(calcd.on anh.substance) |
| Purity(Nonaqueous Titration) | min. 98.0 %(calcd.on anh.substance) |
| Water | max. 10.0 % |
Properties (reference)
| Solubility in water | Soluble |
| Solubility (soluble in) | Methanol, Dimethylformamide |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H360 : May damage fertility or the unborn child. H340 : May cause genetic defects. H351 : Suspected of causing cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
Transport Information:
| HS Number | 2933599590 |
Application
Valganciclovir Hydrochloride: An Oral Prodrug of Ganciclovir, with Enhanced Bioavailability
Valganciclovir is an oral prodrug of ganciclovir [G0315], with enhanced bioavailability than oral ganciclovir. After oral administration, valganciclovir is rapidly converted to ganciclovir by intestinal and hepatic esterases. The involvement of peptide transporter 1 (PEPT1) is indicated for the digestive absorption of valganciclovir.1,2) Ganciclovir is a synthetic analogue of 2’-deoxyguanosine with antiviral activity against members of the herpes group such as cytomegalovirus (CMV) and some other DNA viruses. Valganciclovir also interferes with herpes viral DNA synthesis and replication.3) (The product is for research purpose only.)
References
- 1) Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2
- 2) Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting
- 3) Valganciclovir (a review)
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