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Published TCIMAIL newest issue No.197
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CAS RN: 27314-97-2 | Product Number: T3823
Tirapazamine
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Purity: >98.0%(HPLC)
Synonyms:
- SR 259075
- 3-Aminobenzo[e][1,2,4]triazine 1,4-Dioxide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
167,00 €
|
1 | 29 |
|
| 250MG |
597,00 €
|
Contact Us | 15 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T3823 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__7H__6N__4O__2 = 178.15 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 27314-97-2 |
| Reaxys Registry Number | 179322 |
| PubChem Substance ID | 468592963 |
| Merck Index (14) | 9461 |
| MDL Number | MFCD00132954 |
Specifications
| Appearance | Orange to Red powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
Properties (reference)
| Melting Point | 230 °C(dec.) |
| Maximum Absorption Wavelength | 457(H2O) nm |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | DM0671500 |
Transport Information:
| HS Number | 2933998090 |
Application
Tirapazamine: A Hypoxia-Activated Antitumor Agent
Tirapazamine, also known as SR-4233, is a hypoxia-activated antitumor agent.1-3) It is converted to the reactive one-electron reduction product (radical anion) under hypoxic condition. The radical product abstracts a proton from DNA to form DNA radicals, largely at C4’ on the ribose ring. Tirapazamine can also oxidized such DNA radicals to cytotoxic DNA strand breaks.4) Recently, the antitumor effects of tirapazamine in combination with cisplatin [D3371]3), and tirapazamine prodrugs5) have been studied. (The product is for research purpose only.)
References
- 1) SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells
- 2) SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours (a review)
- 3) The hypoxic cell: a target for selective cancer therapy-eighteenth Bruce F. Cain memorial award lecture
- 4) Selective Potentiation of the Hypoxic Cytotoxicity of Tirapazamine by Its 1-N-Oxide Metabolite SR 4317
- 5) Q6, a novel hypoxia-targeted drug, regulates hypoxia-inducible factor signaling via an autophagy-dependent mechanism in hepatocellular carcinoma
Product Documents (Note: Some products will not have analytical charts available.)
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