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Published TCIMAIL newest issue No.197
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CAS RN: 119413-54-6 | Product Number: T2795
Topotecan Hydrocholoride
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Purity: >95.0%(T)(HPLC)
Synonyms:
- Nogitecan Hydrocholoride
- (4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 250MG |
€95.00
|
1 | 39 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T2795 |
| Purity / Analysis Method | >95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__3H__2__3N__3O__5·HCl = 457.91 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| Packaging and Container | 250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 119413-54-6 |
| Reaxys Registry Number | 5470704 |
| PubChem Substance ID | 468592816 |
| Merck Index (14) | 9548 |
| MDL Number | MFCD00866235 |
Specifications
| Appearance | Light yellow to Yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0% (calcd. on anh. substance) |
| Specific rotation | 100 to 105 deg(C=0.5, water, calcd.on anh.substance) |
| Water | max. 12.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 215 °C(dec.) |
| Maximum Absorption Wavelength | 414(Phosphate buffer sol.) nm |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. H340 : May cause genetic defects. H351 : Suspected of causing cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | UQ0491400 |
Transport Information:
| HS Number | 2939799090 |
Application
Topotecan Hydrocholoride: A Water-Soluble Topoisomerase I Inhibitor
Topotecan hydrocholoride is a topoisomerase I inhibitor that is a semi-synthetic water-soluble derivative of camptothecin [C1495].1) During the course of its normal cell cycle, topoisomerase I relieves torsional strain in DNA by inducing reversible single strand breaks, and transiently forms a covalent bond with DNA. Topotecan prevents the re-ligation of these single-strand breaks by binding to and stabilizing the complex of topoisomerase I and DNA. This process leads to breaks in the DNA strand resulting in apoptosis and cell death.1-3) Recently, lipid nanoencapsulation of topotecan has attracted much attention in order to reduce the loss of efficacy of topotecan due to its hydrolysis in vivo4). (The product is for research purpose only.)
References
- 1) Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity
- 2) Topotecan, a novel topoisomerase I inhibitor. Pharmacology and clinical experience (a review)
- 3) The mechanism of topoisomerase I poisoning by a camptothecin analog
- 4) Development of topotecan loaded lipid nanoparticles for chemical stabilization and prolonged release
- 5) Development and validation of a liquid chromatography-tandem mass spectrometry method for topotecan determination in beagle dog plasma and its application in a bioequivalence study
Product Documents (Note: Some products will not have analytical charts available.)
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