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Published TCIMAIL newest issue No.197
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CAS RN: 53-19-0 | Product Number: M3304
Mitotane
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Purity: >98.0%(GC)
Synonyms:
- 1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane
- 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene
- o,p'-DDD
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€46.00
|
Contact Us | 1 |
|
| 5G |
€147.00
|
Contact Us | 8 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M3304 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__4H__1__0Cl__4 = 320.03 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 53-19-0 |
| Reaxys Registry Number | 2056007 |
| PubChem Substance ID | 468592398 |
| Merck Index (14) | 6216 |
| MDL Number | MFCD00000850 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 76.0 to 80.0 °C |
| Solubility in Methanol | almost transparency |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 78 °C |
| Solubility in water | Insoluble |
| Degree of solubility in water | 0.1 mg/l 25 °C |
| Solubility (soluble in) | Ethanol, Methanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H351 : Suspected of causing cancer. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P260 : Do not breathe dust. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. |
Related Laws:
| RTECS# | KH7880000 |
Transport Information:
Application
Mitotane: An Adrenal-Specific Cytotoxic Agent with Steroid Synthesis Inhibition
Mitotane (o,p'-DDD) is an adrenal-specific cytotoxic agent with an unknown biochemical mechanism of action.1) Scientific reports suggest that mitotane modifies the peripheral metabolism of steroids as well as directly suppressing the adrenal cortex.2-4) Therefore, mitotane is used for the treatment of adrenocortical carcinoma (ACC) and Cushing's disease. Recently, mitotane (as an adjuvant) plus etoposide [E0675], doxorubicin [D4193] (HCl salt), and cisplatin [D3371] (called EDP-M) is the established first-line therapy for ACC.5) (The product is for research purpose only.)
References
- 1) Ultrastructure of Adrenal Cortex of the Dog during Treatment with DDD
- 2) Studies on the site of action of o,p’-DDD in the dog adrenal cortex. 1. Inhibition of ACTH-mediated pregnenolone synthesis
- 3) Changes in corticosteroid synthesis of the human adrenal cortex in vitro, induced by treatment with o,p'-DDD for cushing's syndrome: evidence for the sites of action of the drug
- 4) An Effect of o,p’-DDD on the Extra-adrenal Metabolism of Cortisol in Man
- 5) Update in adrenocortical carcinoma (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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