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Published TCIMAIL newest issue No.197
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CAS RN: 749886-87-1 | Product Number: M2734
4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine
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Purity: >98.0%(GC)
Synonyms:
- JSH-23
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
€311.00
|
1 | 5 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M2734 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__6H__2__0N__2 = 240.35 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| CAS RN | 749886-87-1 |
| Reaxys Registry Number | 24398255 |
| PubChem Substance ID | 253661372 |
| MDL Number | MFCD09753595 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 101.0 to 105.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 103 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| HS Number | 2921599090 |
Application
核内因子κB (NFκB) 活性化阻害剤
This compound, often called as JSH-23, is an inhibitor of nuclear factor-κB (NFκB) transcriptional activity (IC50= 7.1 µM). NFκB is a protein complex controls transcription of DNA and inflammatory cytokine production. JSH-23 has been reported to inhibit lipopolysaccharide(LPS)-induced nuclear translocation of NFκB without affecting the process of NFκB - IκB complex degradation.
References
- Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-κB without affecting IκB degradation
- Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia
- JSH-23 targets nuclear factor-kappa B and reverses various deficits in experimental diabetic neuropathy: affect on neuroinflammation and antioxidant defence
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