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CAS RN: 434-13-9 | Product Number: L0089
Lithocholic Acid
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Purity: >98.0%(T)
Synonyms:
- 5β-Cholanic Acid-3α-ol
- 3α-Hydroxy-5β-cholanic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€54.00
|
2 | ≥60 |
|
| 25G |
€194.00
|
Contact Us | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | L0089 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__2__4H__4__0O__3 = 376.58 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 434-13-9 |
| Reaxys Registry Number | 3217757 |
| PubChem Substance ID | 87572051 |
| SDBS (AIST Spectral DB) | 10707 |
| Merck Index (14) | 5545 |
| MDL Number | MFCD00003682 |
Specifications
| Appearance | White to Almost white powder to crystaline |
| Purity(GC) | min. 97.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 185.0 to 190.0 °C |
| Specific rotation [a]20/D | +33.0 to +38.0 deg(C=1, EtOH) |
Properties (reference)
| Melting Point | 186 °C |
| Specific Rotation | 35.5° (C=1,EtOH) |
| Solubility in water | Insoluble |
| Degree of solubility in water | 0.38 mg/l 25 °C |
| Solubility (slightly sol. in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| EC Number | 207-099-1 |
| RTECS# | FZ2275000 |
Transport Information:
| HS Number | 2918199890 |
Application
Lithocholic acid: A Monohydroxy Secondary Bile Acid
Lithocholic acid is a monohydroxy secondary bile acid that acts as a detergent to solubilize fats for absorption. It is formed in the colon by bacterial 7-dehydroxylation of the primary bile acid chenodeoxycholic acid (CDCA) [C0750] and of the secondary bile acid ursodeoxycholic acid (UDCA) [U0030]. Recently, lithocholic acid is identified as an endogenous ligand of the vitamin D receptor (VDR) and a pregnane X receptor (PXR) activator. Lithocholic acid has been used for several therapeutic purposes in man. (The product is for research purpose only.)
References
- The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
- Vitamin D receptor as an intestinal bile acid sensor
- Detoxification of Lithocholic Acid, A Toxic Bile Acid: Relevance to Drug Hepatotoxicity (a review)
- Mechanisms underlying the anti-aging and anti-tumor effects of lithocholic bile acid (a review)
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