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Published TCIMAIL newest issue No.197
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CAS RN: 148849-67-6 | Product Number: I0847
Ivabradine Hydrochloride
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Purity: >98.0%(HPLC)(N)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
€92.00
|
2 | 10 |
|
| 1G |
€311.00
|
2 | 19 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | I0847 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__2__7H__3__6N__2O__5·HCl = 505.05 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 148849-67-6 |
| Related CAS RN | 155974-00-8 |
| Reaxys Registry Number | 9681567 |
| PubChem Substance ID | 253659556 |
| Merck Index (14) | 5247 |
| MDL Number | MFCD00929899 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Purity(Argentometric Titration) | min. 97.0 % |
| Specific rotation [a]20/D | +6.0 to +8.5 deg(C=1, DMSO) |
Properties (reference)
| Melting Point | 140 °C |
| Specific Rotation | 7° (C=1,DMSO) |
GHS
Related Laws:
Transport Information:
| HS Number | 2933790090 |
Application
Studies of the Selective If Current Inhibitor Ivabradine
References
- Current-dependent block of rabbit sino-atrial node If channels by ivabradine
- Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea pig cardiac preparations: comparison with UL-FS 49
- Coronary and hemodynamic effects of S 16257, a new bradycardic agent, in resting and exercising conscious dogs
- L. Simon, B. Ghaleh, L. Puybasset, J. F. Giudicelli, A. Berdeaux, J. Pharmacol. Exp. Ther. 1995, 275, 659.
- Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells
- Heart rate lowering by specific and selective If current inhibition with ivabradine. A new therapeutic perspective in cardiovascular disease
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