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CAS RN: 145108-58-3 | Product Number: D5062
Dexmedetomidine Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (+)-Medetomidine Hydrochloride
- (S)-4-(α,2,3-Trimethybenzyl)-1H-imidazole Hydrochloride
- (S)-4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 20MG |
€36.00
|
1 | ≥40 |
|
| 100MG |
€140.00
|
1 | 28 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D5062 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__3H__1__6N__2·HCl = 236.74 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 20MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 145108-58-3 |
| Related CAS RN | 113775-47-6 |
| Reaxys Registry Number | 8937629 |
| PubChem Substance ID | 354333214 |
| Merck Index (14) | 2946 |
| MDL Number | MFCD12912677 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Argentometric Titration) | min. 98.0 % |
| Melting point | 156.0 to 160.0 °C |
| Specific rotation [a]20/D | +49.0 to +54.0 deg(C=1, H2O) |
Properties (reference)
| Melting Point | 158 °C |
| Specific Rotation | 51° (C=1,H2O) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | NI5156750 |
Transport Information:
| HS Number | 2933299090 |
Application
Dexmedetomidine Hydrochloride: A Potent and Selective α2-Adrenoceptor Agonist
Dexmedetomidine hydrochloride is a potent α2-adrenoceptor agonist, which produces and analgesia, about 8 times higher selective affinity for the α2/α1-adrenoceptor than clonidine [D1353]. Dexmedetomidine also binds to imidazoline receptors, based on the imidazole group. (The product is for research purpose only.)
References
- Effects of intravenous dexmedetomidine in humans. II. Hemodynamic changes
- Further characterization of the receptor mechanism involved in the antidysrhythmic effect of dexmedetomidine on halothane/epinephrine dysrhythmias in dogs.
- Assessment of the role of α2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice
- The α2-Adrenoceptor Agonist Dexmedetomidine Converges on an Endogenous Sleep-promoting Pathway to Exert Its Sedative Effects
- Dexmedetomidine: a review of its use for sedation in mechanically ventilated patients in an intensive care setting and for procedural sedation
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