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Published TCIMAIL newest issue No.197
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CAS RN: 24390-14-5 | Product Number: D4116
Doxycycline Hyclate
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Purity: >97.0%(HPLC)
Synonyms:
- Doxycycline Hydrochloride Hemiethanolate Hemihydrate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€26.00
|
8 | ≥100 |
|
| 25G |
€104.00
|
2 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D4116 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__4N__2O__8·^^1/__2C__2H__6O·HCl·^^1/__2H__2O = 512.94 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 24390-14-5 |
| Related CAS RN | 10592-13-9&564-25-0 |
| PubChem Substance ID | 172089114 |
| Merck Index (14) | 3440 |
| MDL Number | MFCD07357237 |
Specifications
| Appearance | Light yellow to Amber to Dark green powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Specific rotation [a]20/D | -100 to -107 deg(C=1, 0.01mol/L HCl(MeOH)) |
| Water | 1.4 to 2.8 % |
| Ethanol(NMR) | 4.3 to 6.0 % |
Properties (reference)
| Specific Rotation | -104° (C=1,0.01mol/L HCl(MeOH)) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
Transport Information:
| HS Number | 2941900000 |
Application
Studies on the Antibacterial Activity of Doxycycline
References
- Doxycycline revisited
- Development and evaluation of novel biodegradable microspheres based on poly(D,L-lactide-co-glycolide) and poly(ε-caprolactone) for controlled delivery of doxycycline in the treatment of human periodontal pocket: In vitro and in vivo studies
- Subantimicrobial dose doxycycline as adjunctive treatment for periodontitis.
- Subantimicrobial dose doxycycline as an adjunct to scaling and root planing: Post-treatment effects
Application
Applications of Doxycycline to Biogenetics Studies
References
- Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice
- Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity
- piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
- Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector
- Transcriptional activation by tetracyclines in mammalian cells
- M. Gossen, S. Freundlieb, G. Bender, G. Muller, W. Hillen, H. Bujard, Science 1995, 268, 1766.
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