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Published TCIMAIL newest issue No.197
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CAS RN: 4342-03-4 | Product Number: D3634
Dacarbazine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- DTIC
- 5-(3,3-Dimethyltriazeno)imidazole-4-carboxamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
62,00 €
|
1 | 17 |
|
| 5G |
199,00 €
|
2 | 3 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D3634 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__6H__1__0N__6O = 182.19 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 4342-03-4 |
| Reaxys Registry Number | 521487 |
| PubChem Substance ID | 87560054 |
| Merck Index (14) | 2798 |
| MDL Number | MFCD00057167 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 255 °C(dec.) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H351 : Suspected of causing cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. |
Related Laws:
| EC Number | 224-396-1 |
| RTECS# | NI3950000 |
Transport Information:
| HS Number | 2933299090 |
Application
Dacarbazine: A Triazene Alkylating Agent with Antitumor and Mutagenic Properties
Dacarbazine (DTIC) is a triazene alkylating agent with antitumor and mutagenic properties, such as temozolomide [T2744]. DTIC is a prodrug that is metabolized to 5-(3-methyl-1-triazeno)imidazole-4-carboxamide (MTIC) which serves to transport a methylating agent (diazomethane) to the O 6 position of guanine within the major groove of DNA that generate base/base mismatches with cytosine and with thymine. These adduct lead to cell death, or if the cell survives, provoke mutations in DNA helix. DTIC is used for the treatment of melanoma. (The product is for research purpose only.)
References
- Antitumor imidazotetrazines. XXIII. Comparison of the cytotoxicity in vitro of temozolomide and dacarbazine, prodrugsof 3-methyl(triazen-1-yl)imidazole-4-carboxamide
- Dacarbazine-based chemotherapy for metastatic melanoma: Thirty-year experience overview (a review)
- Re-evaluating the role of dacarbazine in metastatic melanoma: what have we learned in 30 years? (a review)
- Triazene compounds: Mechanism of action and related DNA repair systems
- Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
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