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CAS RN: 152-53-4 | Product Number: C3900
Cycloguanil Hydrochloride
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Purity: >95.0%(T)(HPLC)
Synonyms:
- Chloroguanide Triazine Hydrochloride
- 1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
€135.00
|
Contact Us | 22 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C3900 |
| Purity / Analysis Method | >95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__1H__1__4ClN__5·HCl = 288.18 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 152-53-4 |
| Reaxys Registry Number | 3751988 |
| MDL Number | MFCD00035308 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Precipitation Titration) | min. 95.0 % |
| Melting point | 209.0 to 213.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 211 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | GU2625000 |
Transport Information:
| HS Number | 2933698090 |
Application
Cycloguanil Hydrochloride: An Inhibitor of Dihydrofolate Reductase (DHFR)
Cycloguanil hydrochloride is an inhibitor of dihydrofolate reductase (DHFR).1-3) By blocking DHFR activity, cycloguanil prevents the production of tetrahydrofolic acid, an essential coenzyme involved in DNA and RNA synthesis. In addition, cycloguanil is an active metabolite of proguanil, produced by the P450 2C19 isoform. Cycloguanil hydrochloride is used as an antimalarial agent used in combination reagent with the other antimalarial atovaquone [A2545] against Plasmodium infections.4) (The product is for research purpose only.)
References
- 1) Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance
- 2) Dihydrofolate reductase and antifolate resistance in malaria (a review)
- 3) Malarial (Plasmodium falciparum) dihydrofolate reductase-thymidylate synthase: structural basis for antifolate resistance and development of effective inhibitors (a review)
- 4) Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro
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