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Published TCIMAIL newest issue No.197
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CAS RN: 55-21-0 | Product Number: B0012
Benzamide
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Purity: >99.0%(N)
Synonyms:
- Benzoylamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
€30.00
|
4 | ≥60 |
|
| 500G |
€167.00
|
1 | 7 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B0012 |
| Purity / Analysis Method | >99.0%(N) |
| Molecular Formula / Molecular Weight | C__7H__7NO = 121.14 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 55-21-0 |
| Reaxys Registry Number | 385876 |
| PubChem Substance ID | 87563226 |
| SDBS (AIST Spectral DB) | 1689 |
| Merck Index (14) | 1060 |
| MDL Number | MFCD00007968 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 99.0 % |
| Melting point | 127.0 to 130.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 128 °C |
| Boiling Point | 288 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 200-227-7 |
| RTECS# | CU8700000 |
Transport Information:
| HS Number | 2924297099 |
Application
Benzamide: An Inhibitor of Poly (ADP-Ribose) Polymerase (PARP) Enzymes
Genomic instability is a hallmark of cancer and is often the result of altered DNA repair capabilities in tumor cells. Poly (ADP-ribose) polymerases (PARPs) are enzymes responsible for DNA damage detection and repair factor recruitment. PARP inhibitors are able to interact with the binding site for the PARP cofactor NAD+ and trap PARP on DNA, and induce cell death through replication stress-induced mitotic catastrophe. It has been reported that benzamide is a PARP inhibitor and has neuroprotective effects. (The product is for research use only.)
References
- Benzamide, an inhibitor of poly(ADP-ribose) polymerase, attenuates methamphetamine-induced dopamine neurotoxicity in the C57Bl/6N mouse
- Poly(ADP-ribose) polymerase inhibitors protect against MPTP-induced depletions of striatal dopamine and cortical noradrenaline in C57B1/6 mice
- Chapter 10, Clinical Development of the Nicotinamides and Benzamides Involving PARP as a Molecular Target (a review)
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
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Other Documents
Related Products
Benzamide Zone Refined (number of passes:20)
| Product # | B0220 |
| CAS RN | 55-21-0 |
| Purity / Analysis Method: | >99.0%(HPLC) |