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Published TCIMAIL newest issue No.197
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CAS RN: 170729-80-3 | Product Number: A3135
Aprepitant
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Purity: >98.0%(HPLC)
Synonyms:
- 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
€75.00
|
1 | 32 |
|
| 500MG |
€239.00
|
1 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A3135 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__3H__2__1F__7N__4O__3 = 534.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 500MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 170729-80-3 |
| Reaxys Registry Number | 8096869 |
| PubChem Substance ID | 354334991 |
| Merck Index (14) | 753 |
| MDL Number | MFCD08277635 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Melting point | 249.0 to 253.0 °C |
| Specific rotation [a]20/D | +67.0 to +71.0 deg(C=1,MeOH) |
Properties (reference)
| Melting Point | 252 °C |
| Specific Rotation | 69° (C=1,MeOH) |
| Solubility in water | Insoluble |
| Solubility (slightly sol. in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H319 : Causes serious eye irritation. H351 : Suspected of causing cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. |
Related Laws:
| RTECS# | XZ5480400 |
Transport Information:
| HS Number | 2934999090 |
Application
Aprepitant: A Selective High-Affinity Antagonist of the Substance P/Neurokinin 1 (NK1) Receptors
Aprepitant is a selective high-affinity antagonist of the substance P/neurokinin 1 (NK1) receptors. Aprepitan crosses the blood barrier, and then aprepitan occupies brain NK1 receptors and blocks the binding of substance P to the receptors. (Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator.) Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors. Aprepitant is used for the treatment of nausea and vomiting. (The product is for research purpose only.)
References
- Aprepitant - a novel NK1-receptor antagonist (a review)
- Aprepitant: A review of its use in the prevention of chemotherapy-induced nausea and vomiting
- Development of aprepitant, the first neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting (a review)
- Simultaneous determination of Aprepitant and two metabolites in human plasma by high-performance liquid chromatography with tandem mass spectrometric detection
- A sensitive and rapid liquid chromatography-tandem mass spectrometry method for the quantification of the novel neurokinin-1 receptor antagonist aprepitant in rhesus macaque plasma, and cerebral spinal fluid, and human plasma with application in translational NeuroAIDs research
- A validated stability indicating RP-HPLC method for the determination of aprepitant in bulk and pharmaceutical dosage forms
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
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