Published TCIMAIL newest issue No.196
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 549-18-8 | Product Number: A0908
Amitriptyline Hydrochloride
×
![]()
×
Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
€81.00
|
1 | ≥60 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A0908 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__3N·HCl = 313.87 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 549-18-8 |
| Related CAS RN | 50-48-6 |
| Reaxys Registry Number | 4164595 |
| PubChem Substance ID | 87562417 |
| Merck Index (14) | 487 |
| MDL Number | MFCD00012537 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 195.0 to 199.0 °C |
| Solubility in Water | almost transparency |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 195 °C |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 208-964-6 |
| RTECS# | HO9450000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2921490090 |
Application
Amitriptyline Hydrochloride: An Inhibitor of Serotonin or Noradrenaline Re-Uptake Transporters
Amitriptyline hydrochloride is the most widely used tricyclic antidepressant agent with sedative effects. The mechanism of action of amitriptyline is still not fully understood. However, amitriptyline works as an inhibitor of serotonin (5-hydroxytryptamine, 5HT [S0370]) or L-noradrenaline [A0906] re-uptake transporters in brain neurons. This inhibition is believed by some to underlie the antidepressant activity of amitriptyline. Amitriptyline undergoes extensive metabolism in the liver, primarily through N-demethylation, to nortriptyline [N0957]. (The product is for research purpose only.)
References
- Inhibition of uptake of tritiated-noradrenaline in the intact rat brain by imipramine and structurally related compounds
- Inhibition of the uptake of tritiated 5-hydroxytryptamine in brain tissue
- Amitriptyline hydrochloride (a review on the physical properties, synthesis, stability, metabolism, and analysis of amitriptyline-HCl)
- Amitriptyline A review of its pharmacological properties and therapeutic use in chronic pain states (a review)
- The Metabolic Fate of Amitriptyline, Nortriptyline and Amitriptylinoxide in Man (a review)
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.