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CAS RN: 155141-29-0 | Product Number: R0271
Rosiglitazone Maleate
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Purity: >95.0%(T)(HPLC)
Synonyms:
- 5-[4-[2-[Methyl(2-pyridinyl)amino]ethoxy]benzyl]-1,3-thiazolidine-2,4-dione (2Z)-2-Butenedioate
- 5-[4-[2-[Methyl(pyridin-2-yl)amino]ethoxy]benzyl]thiazolidine-2,4-dione Maleate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
$62.00
|
≥60 | 0 | Contact Us | |
| 5G |
$214.00
|
39 | 0 | Contact Us |
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* The storage conditions are subject to change without notice.
| Product Number | R0271 |
| Purity / Analysis Method | >95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__1__9N__3O__3S·C__4H__4O__4 = 473.50 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 155141-29-0 |
| Reaxys Registry Number | 7966066 |
| MDL Number | MFCD03427306 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Melting point | 115.0 to 119.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 117 °C |
GHS
Related Laws:
| RTECS# | XJ5813870 |
Transport Information:
| H.S.code* | 2934.10-000 |
Application
Rosiglitazone Maleate: An Agonist at the Peroxisome Proliferator-Activated Receptor of the Gamma Subtype (PPARγ)
Rosiglitazone maleate and rosiglitazone (free base) [R0106] are agonists at the peroxisome proliferator-activated receptor gamma subtype (PPARγ), a transcriptional regulator. PPAR receptors are found in peripheral tissues that are important for insulin action. Activation of PPARγ nuclear receptors modulates the transcription of a number of insulin-responsive genes involved in the control of glucose and lipid metabolism. Therefore, rosiglitazone decreases insulin resistance in peripheral tissues and in the liver, resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. Recently, rosiglitazone has been reported to be associated with cardiovascular problems. (The product is for research use only.)
References
- A review of rosiglitazone in type 2 diabetes mellitus (a review)
- Potential remains for PPAR-targeted drugs (a review)
- Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality (a review)
- Spectrophotometric and HPLC determinations of anti-diabetic drugs, rosiglitazone maleate and metformin hydrochloride, in pure form and in pharmaceutical preparations
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