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CAS RN: 253168-94-4 | Product Number: E1381
1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine
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Purity: >98.0%(GC)(T)
Synonyms:
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
$28.00
|
15 | 6 | Contact Us | |
| 5G |
$91.00
|
12 | 10 | Contact Us |
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| Product Number | E1381 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__1__2H__1__9NO__4S = 273.35 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 253168-94-4 |
| Reaxys Registry Number | 13730415 |
| PubChem Substance ID | 468591748 |
| MDL Number | MFCD27665207 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 119.0 to 123.0 °C |
| Solubility in Methanol | almost transparency |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 120 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| H.S.code* | 2930.90-900 |
Application
A Synthetic Intermediate of Apremilast
This product is used as a synthetic intermediate of apremilast, a selective phosphodiesterase 4 (PDE4) inhibitor.
References
- Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and TumorNecrosis Factor-α Inhibitor
- Enantioselective synthesis of the apremilast aminosulfone using catalytic asymmetric hydrogenation
- Identification, characterization and HPLC quantification of impurities in apremilast
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