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CAS RN: 149198-47-0 | Product Number: B5715
tert-Butyl (3R,4S)-2-Oxo-4-phenyl-3-[(triethylsilyl)oxy]azetidine-1-carboxylate
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Purity: >97.0%(HPLC)
Synonyms:
- (3R,4S)-2-Oxo-4-phenyl-3-[(triethylsilyl)oxy]azetidine-1-carboxylic Acid tert-Butyl Ester
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
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| 1G |
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| Product Number | B5715 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__3__1NO__4Si = 377.56 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 149198-47-0 |
| Reaxys Registry Number | 6345072 |
| PubChem Substance ID | 354335618 |
| MDL Number | MFCD08273948 |
Specifications
| Appearance | Colorless to Light yellow clear liquid |
| Purity(HPLC) | min. 97.0 area% |
| Purity(with Total Nitrogen) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Flash point | 234 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2933.79-000 |
Application
A β-lactam Synthon for the Synthesis of Microtubule-Stabilizing Antitumor Agents
This reagent has been used as a β-lactam synthon for the synthesis of microtubule-stabilizing antitumor agents, such as paclitaxel [P1632], docetaxel [D4102] and 10-deacetylbaccatin III [D4148].
References
- A highly efficient route to taxotere by the β-lactam synthon method
- A chemoselective approach to functionalize the C-10 position of 1-deacetylbaccatin III. Synthesis and biological properties of novel C-10® Taxol analogs
- Total synthesis of a library of designed hybrids of the microtubule-stabilizing anticancer agents taxol, discodermolide and dictyostatin
- Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents
PubMed Literature
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