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CAS RN: 29122-68-7 | Product Number: A1414
Atenolol
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Purity: >98.0%(T)
Synonyms:
- 2-[4-(2-Hydroxy-3-isopropylaminopropoxy)phenyl]acetamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 10G |
$158.00
|
27 | ≥40 |
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| Product Number | A1414 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__1__4H__2__2N__2O__3 = 266.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 29122-68-7 |
| Reaxys Registry Number | 2739235 |
| PubChem Substance ID | 87562869 |
| SDBS (AIST Spectral DB) | 16620 |
| Merck Index (14) | 859 |
| MDL Number | MFCD00057645 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Solubility in Methanol | almost transparency |
| Melting point | 151.0 to 155.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 154 °C |
| Solubility in water | Slightly soluble |
| Degree of solubility in water | 13.3 g/l 25 °C |
| Solubility (insoluble in) | Chloroform |
GHS
Related Laws:
| RTECS# | AC3600000 |
Transport Information:
| H.S.code* | 2924.29-000 |
Application
Atenolol: A Selective β1 Adrenergic Receptor Antagonist
Atenolol is a selective β1 adrenergic receptor antagonist (β1-blocker). β1-Adrenergic receptors are located mainly in the heart and in the kidneys. β1 Adrenergic receptor antagonists (eg. atenolol, metoprolol tartrate [M2555], bisoprolol hemifumarate [B3994] and nebivolol hydrochloride [N0954]) protect the heart against the oxygen-consuming effects of sympathetic stimulation by blocking β1 adrenergic receptors. β1 adrenergic receptor antagonists also serve to reduce the heart rate and protect the failing heart against excessive sympathetic drive. Atenolol is a racemic mixture and its activity resides in the S-enantiomer. (The product is for research purpose only.)
References
- Atenolol: A review of its pharmacological properties and therapeutic efficacy in angina pectoris and hypertension
- Atenolol: pharmacokinetic/dynamic aspects of comparative developmental toxicity
- Atenolol (a review of the synthesis, physical properties, methods of detection. in pharmaceuticals and body fluids, stability and degradation, drug metabolism and pharmacokinetics of atenolol)
- Enantioselective bioanalysis of beta-blocking agents: focus on atenolol, betaxolol, carvedilol, metoprolol, pindolol, propranolol and sotalol
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