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Published TCIMAIL newest issue No.197
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CAS RN: 2182-14-1 | Product Number: V0193
Vindoline
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Purity: >98.0%(HPLC)(qNMR)
Synonyms:
- Methyl (3aR,3a1R,4R,5S,5aR,10bR)-4-Acetoxy-3a-ethyl-5-hydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
155,00 €
|
Contact Us | 20 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | V0193 |
| Purity / Analysis Method | >98.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__2__5H__3__2N__2O__6 = 456.54 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 2182-14-1 |
| Reaxys Registry Number | 68801 |
| MDL Number | MFCD27991347 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 98.0 % |
| Melting point | 162.0 to 166.0 °C |
| Specific rotation | -59.0 to -65.0 deg(C=1.5, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 164 °C |
GHS
Related Laws:
| EC Number | 218-558-0 |
| RTECS# | CJ0120000 |
Transport Information:
| HS Number | 2939799090 |
Application
Vindoline: A Chemical Precursor of Antitumor Vinca Alkaloids
Vindoline is an alkaloid found in the leaves of Catharanthus roseus.1,2) Vindoline has been used as a chemical precursor of vincristine [V0129] and vinblastine, antitumor vinca alkaloids.3,4)
References
- 1) Screening of Catharanthus roseus secondary metabolites by high-performance liquid chromatography
- 2) Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast
- 3) Total Synthesis of Vinblastine, Vincristine, Related Natural Products, and Key Structural Analogues
- 4) Modifications on the basic skeletons of vinblastine and vincristine (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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