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CAS RN: 2068-78-2 | Product Number: V0129
Vincristine Sulfate
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Purity: >95.0%(HPLC)
Synonyms:
- VCR
- Leurocristine Sulfate
- 22-Oxovincaleukoblastine Sulfate
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 25MG |
$176.00
|
Contact Us | Contact Us | 2 |
|
| 100MG |
$441.00
|
Contact Us | Contact Us | 15 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | V0129 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__4__6H__5__6N__4O__1__0·H__2SO__4 = 923.04 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic,Heat Sensitive |
| CAS RN | 2068-78-2 |
| Reaxys Registry Number | 8047628 |
| PubChem Substance ID | 468593101 |
| Merck Index (14) | 9986 |
| MDL Number | MFCD08706469 |
Specifications
| Appearance | White to Light yellow powder to crystaline |
| Purity(HPLC) | min. 95.0 area% |
| Specific rotation [a]20/D | +24.0 to +32.0 deg(C=2, H2O，calcd.on dried substance) |
| Drying loss | max. 15.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 300 °C |
| Maximum Absorption Wavelength | 293(MeOH) nm |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H361 : Suspected of damaging fertility or the unborn child. H341 : Suspected of causing genetic defects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | OH6340000 |
Transport Information:
| UN Number (DOT-AIR) | UN2811 |
| Class (DOT-AIR) | 6.1 |
| Packing Group (TCI-A) | II |
| HS Number | 2939.79.0000 |
Application
Vincristine Sulfate: An Antitumor Vinca Alkaloid
Vincristine Sulfate is an antitumor vinca alkaloid obtained from a common flowering herb, the periwinkle plant (Vinca rosea Linn). The exact mechanism of action has not been determined, but vincristine sulfate has been related to the inhibition of microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. Vincristine has been reported to have neurotoxic side effects. However, the liposome encapsulation of vincristine enhances the efficacy of the vincristine antitumor activity while simultaneously decreasing the neurotoxicity associated with it. (The product is for research purpose only.)
References
- Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle (a review)
- The effect of antimicrotubule agents on signal transduction pathways of apoptosis. A review
- Marqibo® (vincristine sulfate liposome injection) improves the pharmacokinetics and pharmacodynamics of vincristine
- Vincristine sulfate. (Supplement) (A review with 80 references description, physical properties, isolation, synthesis, pharmacokinetics, preparation and preservation, uses and methods of analysis.)
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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