Maximum quantity allowed is 999
Please select the quantity
Histon Deacetylase 8 (HDAC8) Selective Inhibitor
No.158(July 2013)
NCC-149 (1), developed by Suzuki, Miyata et al., selectively inhibits histon deacetylase 8 (HDAC8). Histon deacetylase (HDAC) regulates gene expression, such as the tumor-suppressor gene, by catalyzing the deacetylation reaction of the acetylated lysine residue in histon. HDAC8, an isoform of histon deacetylase, has been reported to be implicated in T-cell lymphomas and neuroblastoma tumorigenesis. It is expected that NCC-149 will be used as an epigenetics research tool and an anticancer agent because of its selective inhibitory activity of HDAC8 and tumor cell growth.
References
- 1)T. Suzuki, Y. Ota, Y. Kasuya, M. Mutsuga, Y. Kawamura, H. Tsumoto, H. Nakagawa, M. G. Finn, N. Miyata, Angew. Chem. Int. Ed. 2010, 49, 6817.
- 2)T. Suzuki, Y. Ota, M. Ri , M. Bando, A. Gotoh, Y. Itoh, H. Tsumoto, P. R. Tatum, T. Mizukami, H. Nakagawa, S. Iida, R. Ueda, K. Shirahige, N. Miyata, J. Med. Chem. 2012, 55, 9562.
Related Compounds
The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.