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CAS RN: 211555-04-3 | Product Number: W0013
WHI-P154
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Purity: >98.0%(HPLC)
Synonyms:
- 2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 10MG |
¥205.00
|
1 | Contact Us | ≥40 |
| 50MG |
¥790.00
|
Contact Us | Contact Us | ≥40 |
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| Product Number | W0013 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__4BrN__3O__3 = 376.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 211555-04-3 |
| Reaxys Registry Number | 8787580 |
| PubChem Substance ID | 468593122 |
| MDL Number | MFCD02179366 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 228.0 to 232.0 °C |
| Elemental analysis(Nitrogen) | 10.50 to 11.50 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 230 °C |
| Maximum Absorption Wavelength | 335(MeOH) nm |
GHS
| Hazard Statements | H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
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| Customs Control Conditions (Q) |
Application
WHI-P 154: A Potent Janus-Associated Kinase 3 (JAK3) Inhibitor
WHI-P 154 is a potent Janus-associated kinase 3 (JAK3) inhibitor that displays no activity at JAK1 or JAK2. JAK3 is a cytoplasmic protein tyrosine kinase that functions in the initiation of cytokine-triggered signal transduction by catalyzing the phosphorylation of signal transduction and activators of transcription (STAT). The phosphorylated SATAs are translocated to the nucleus to activate target genes. WHI-P 154 is cytotoxic human glioblastoma cells. Recent reports have indicated that JAK3 is expressed in lymphoid cells and is involved in the signaling of T cell functions. Therefore, the development of a selective JAK3 inhibitor has been shown to have a potential benefit in the treatment of autoimmune disorders. (The product is for research purpose only.)
References
- 4-(3'-Bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: a novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cells
- Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3
- The specificity of JAK3 kinase inhibitors
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