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CAS RN: 251992-66-2 | Product Number: T3498
4-(p-Tolylthio)thieno[2,3-c]pyridine-2-carboxamide
![Thumbnail of 4-(p-Tolylthio)thieno[2,3-c]pyridine-2-carboxamide](/medias/T3498.jpg?context=bWFzdGVyfHJvb3R8MTQ1MzF8aW1hZ2UvanBlZ3xhR0kwTDJnNE1TODRPVE0zTURneU5URTVOVGd5TDFRek5EazRMbXB3Wnd8YmY0Zjc1ZWQ1MTVjMTAwZDg2MDhkYjljNGE5ZmExMjRmNTFkZTQzNDQ5NjAyYzFkODJjN2ZkNzc5NWMzMmQ2OA "4-(p-Tolylthio)thieno[2,3-c]pyridine-2-carboxamide")
![Chemical Structure of 4-(p-Tolylthio)thieno[2,3-c]pyridine-2-carboxamide](/medias/T3498.jpg?context=bWFzdGVyfHJvb3R8NDQwOTN8aW1hZ2UvanBlZ3xhR00xTDJnNFlTODRPVEl6TmpFeE16azRNVGMwTDFRek5EazRMbXB3Wnd8MWI4ZTU5MDhkODA0YjRjMzFjY2JkMWE2Y2ExYjg0YjM4MDcyNTNmOTZlZjIwOWQwYmNlMGQ5Mjg2NTAzYzM0ZA "4-(p-Tolylthio)thieno[2,3-c]pyridine-2-carboxamide")
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Purity: >95.0%(HPLC)
Synonyms:
- 4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide
- A 205804
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 25MG |
¥415.00
|
Contact Us | Contact Us | 9 |
| 100MG |
¥1,655.00
|
Contact Us | Contact Us | 16 |
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| Product Number | T3498 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__2N__2OS__2 = 300.39 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 251992-66-2 |
| Reaxys Registry Number | 8847872 |
| PubChem Substance ID | 354334760 |
| MDL Number | MFCD09038566 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Elemental analysis(Nitrogen) | 8.80 to 9.80 % |
| Melting point | 198.0 to 202.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 200 °C |
GHS
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Transport Information:
| Customs Control Conditions (Q) |
Application
An Inhibitor of the Induced Expression of Intercellular Adhesion Molecule-1 (ICAM-1) and E-Selection
It is reported that this compound is a potent and selective inhibitor of the induced expression of E-selection and intercellular adhesion molecule-1 (ICAM-1) relative to vascular cell adhesion molecule-1 (VCAM-1). For your information, E-selectin, ICAM-1, and VCAM-1 play a role in cell adhesion to the vascular endothelium. E-selectin is expressed on inflamed vascular endothelial cells in response to treatment with inflammatory cytokines.
References
- Discovery of Inhibitors of Cell Adhesion Molecule Expression in Human Endothelial Cells. 1. Selective Inhibition of ICAM-1 and E-Selectin Expression
- Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
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