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CAS RN: 145821-59-6 | Product Number: T3165
Tiagabine Hydrochloride
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Purity: >99.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 50MG |
¥265.00
|
1 | 1 | Contact Us |
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| Product Number | T3165 |
| Purity / Analysis Method | >99.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__5NO__2S__2·HCl = 412.00 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic,Heat Sensitive |
| CAS RN | 145821-59-6 |
| Related CAS RN | 115103-54-3 |
| Reaxys Registry Number | 6378452 |
| PubChem Substance ID | 253662389 |
| Merck Index (14) | 9417 |
| MDL Number | MFCD07369025 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 189.0 to 194.0 °C |
| Specific rotation [a]20/D | -9.0 to -12.0 deg(C=1, H2O) |
Properties (reference)
| Melting Point | 193 °C |
| Specific Rotation | -11° (C=1.0,H2O) |
| Solubility in water | Soluble |
GHS
Related Laws:
| RTECS# | TM6128245 |
Transport Information:
| Customs Control Conditions (Q) |
Application
Tiagabine hydrochloride: A Potent and Selective Anticonvulsant GABA Uptake Inhibitor of Neuronal GABA Transporter
γ-Aminobutyric acid (GABA) [A0282] is considered to be the major inhibitory neuro-transmitter in the brain and loss of GABA inhibition has been clearly implicated in. Tiagabine hydrochloride is a potent and selective anticonvulsant GABA uptake inhibitor of the principal neuronal GABA transporter 1 (GAT-1) in the cortex and hippocampus. Tiagabine elevates synaptic GABA levels by inhibiting GAT-1. (The product is for research purpose only.)
References
- The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (Tiagabine) as an anticonvulsant drug candidate
- Tiagabine, SK and F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1
- Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabapentin in mouse models of acute, prolonged, and chronic nociception
- Basic mechanisms of gabitril (tiagabine) and future potential developments (a review)
- Tiagabine (a review: development, mechanism of action, clinical pharmacokinetics, efficacy, adverse effects, drug interactions, clinical uses, and therapeutic potential.)
- Drug interactions involving the new second- and third-generation antiepileptic drugs
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