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CAS RN: 2398-96-1 | Product Number: T3059
Tolnaftate
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Purity: >97.0%(HPLC)(N)
Synonyms:
- O-2-Naphthyl Methyl(3-methylphenyl)carbamothioate
- Methyl(3-methylphenyl)carbamothioic Acid O-2-Naphthyl Ester
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 1G |
¥140.00
|
2 | Contact Us | 19 |
| 5G |
¥190.00
|
2 | 1 | 12 |
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| Product Number | T3059 |
| Purity / Analysis Method | >97.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__9H__1__7NOS = 307.41 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 2398-96-1 |
| Reaxys Registry Number | 2752620 |
| PubChem Substance ID | 253661582 |
| Merck Index (14) | 9519 |
| MDL Number | MFCD00056611 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| Melting point | 111.0 to 115.0 °C |
Properties (reference)
| Melting Point | 113 °C |
| Maximum Absorption Wavelength | 258(MeOH) nm |
| Solubility in water | Insoluble |
| Solubility (slightly sol. in) | Ether |
GHS
Related Laws:
| RTECS# | FD8891300 |
Transport Information:
| Customs Control Conditions (Q) |
Application
Tolnaftate: A Synthetic Antifungal Reagent
Tolnaftate is a chemical synthetic antifungal reagent. Although the exact mechanism of action is not entirely known, tolnaftate would inhibit sterol biosynthesis at the level of squalene epoxidase which is an important enzyme in the biosynthetic pathway of the fungal membrane.
References
- The mode of antifungal action of tolnaftate
- Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate
- Tolnaftate (a review)
- Spectrophotometric methods for the determination of tolnaftate
- Analysis of some antifungal drugs by spectrophotometric and spectrofluorimetric methods in different pharmaceutical dosage forms
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Articles/Brochures
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