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CAS RN: 304909-07-7 | Product Number: S0971
SANT-1
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Purity: >95.0%(GC)
Synonyms:
- N-(4-Benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 5MG |
¥95.00
|
Contact Us | Contact Us | 19 |
| 25MG |
¥130.00
|
Contact Us | Contact Us | 20 |
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| Product Number | S0971 |
| Purity / Analysis Method | >95.0%(GC) |
| Molecular Formula / Molecular Weight | C__2__3H__2__7N__5 = 373.50 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Moisture Sensitive,Heat Sensitive |
| CAS RN | 304909-07-7 |
| Reaxys Registry Number | 15638831 |
| MDL Number | MFCD01827306 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(GC) | min. 95.0 % |
| Melting point | 108.0 to 112.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 110 °C |
GHS
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| Customs Control Conditions (Q) |
Application
SANT-1: A Smoothened (SMO) Antagonist
Smoothened (SMO) is a member of the Frizzled family of seven transmembrane proteins (GPCRs). SMO mediates signal transduction in the hedgehog pathway, which is implicated in normal development and carcinogenesis. It has been reported that SANT-1 is a SMO antagonist which has anti-tumour effect through its ability to bind to smoothened protein.
References
- Evidence for allosteric interactions of antagonist binding to the Smoothened receptor
- Guggulsterone sensitizes glioblastoma cells to Sonic hedgehog inhibitor SANT-1 induced apoptosis in a Ras/NFκB dependent manner
- I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs (a review)
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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