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CAS RN: 138489-18-6 | Product Number: R0257
Ro 31-8220 Mesylate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- Bisindolylmaleimide IX
- 3-[3-[4-(1-Methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl Carbamimidothioate Methanesulfonate
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 10MG |
¥790.00
|
4 | Contact Us | ≥40 |
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| Product Number | R0257 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__5H__2__3N__5O__2S·CH__4O__3S = 553.65 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 138489-18-6 |
| Reaxys Registry Number | 5373685 |
| MDL Number | MFCD03788207 |
Specifications
| Appearance | Orange to Red powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Melting point | 237.0 to 241.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 239 °C |
GHS
Related Laws:
| RTECS# | FD3070500 |
Transport Information:
| Customs Control Conditions (Q) |
Application
Ro 31-8220 Mesylate: A Potent, Cell-Permeable Inhibitor of Protein Kinase C (PKC)
Ro 31-8220 mesylate (bisindolylmaleimide IX) is a potent, cell-permeable inhibitor of protein kinase C (PKC) isoforms, which is an important element in the signal transduction pathways of a variety of hormones, cytokines, and growth factors.1,2) In addition, Ro 31-8220 mesylate is inhibits glycogen synthase kinase 3.3) There are reports, that Ro 31-8220 mesylate inhibits LRRK2 (Leucine-rich repeat kinase 2) –G2019S that is a promising therapeutic target for the treatment of Parkinson's disease.4,5) (The product is for research purpose only.)
References
- 1) Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C
- 2) Protein kinase C in the treatment of disease: signal transduction pathways, inhibitors, and agents in development (a review)
- 3) The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity
- 4) Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
- 5) Investigation of leucine-rich repeat kinase 2: Enzymological properties and novel assays
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