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CAS RN: 53797-35-6 | Product Number: R0194
Ribostamycin Sulfate
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Purity: >90.0%(N)
Synonyms:
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 1G |
¥390.00
|
Contact Us | Contact Us | 3 |
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| Product Number | R0194 |
| Purity / Analysis Method | >90.0%(N) |
| Molecular Formula / Molecular Weight | C__1__7H__3__4N__4O__1__0·xH__2SO__4 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 53797-35-6 |
| Related CAS RN | 25546-65-0 |
| Reaxys Registry Number | 8820400 |
| PubChem Substance ID | 354335294 |
| Merck Index (14) | 8206 |
| MDL Number | MFCD00057496 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Specific rotation [a]20/D | +41.0 to +45.0 deg(C=1,H2O) |
| Drying loss | max. 5.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 180 °C |
| Specific Rotation | 44° (C=1,H2O) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H360 : May damage fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
Transport Information:
| Customs Control Conditions (Q) | Q类 （糖类，生物碱类，抗生素类，激素类） |
Application
Ribostamycin Sulfate: A Broad-Spectrum Aminoglycoside Antibiotic
Ribostamycin sulfate (SF-733) is a broad-spectrum aminoglycoside antibiotic isolated from Streptomyces ribosifidicus. It has activity against both Gram-negative and Gram-positive bacteria but has no activity against yeasts or fungi. Ribostamycin irreversibly binds to the 30S subunit (16S rRNA) of the bacterial ribosome as with any other aminoglycoside antibiotics, and then it inhibits bacterial growth by inhibiting protein synthesis. (The product is for research purpose only.)
References
- Antibiotic SF-733, a new antibiotic. I. Taxonomy, isolation, and characterization
- In vitro activity of mezlocillin, meropenem, aztreonam, vancomycin, teicoplanin, ribostamycin, and fusidic acid against Borrelia burgdorferi
- Ribostamycin inhibits the chaperone activity of protein disulfide isomerase
- Binding of neomycin-class aminoglycoside antibiotics to the A-site of 16 S rRNA
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