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CAS RN: 148553-50-8 | Product Number: P2840

Pregabalin

Purity: >98.0%(T)

Synonyms:

(S)-3-(Aminomethyl)-5-methylhexanoic Acid

Product Documents:

Size	Unit Price	Shanghai	Tianjin	Japan*
10MG	¥110.00	3	31	≥40
50MG	¥290.00	22	1	≥60

* For order or inquiry, please contact Our Authorized Distributors.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
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Supplemental Product Information:

It is strictly forbidden to use this product for any research, production, or sale of illegal drugs.
It is strictly forbidden to export this product to the United States, Canada, Mexico, Colombia, and other countries.
Any legal issues arising from the above two clauses shall be borne by the buyer of this contract, and the supplier shall not be responsible.

General Information plus

Specifications & Documents plus

Specifications

Appearance	White to Almost white powder to crystal
Purity(Nonaqueous Titration)	min. 98.0 %
Specific rotation	+10.0 to +12.0 deg (C=1, Water)
NMR	confirm to structure

Properties (reference)

Safety & Properties plus

GHS

Pictogram
Signal Word	Warning
Hazard Statements	H361 : Suspected of damaging fertility or the unborn child.
Precautionary Statements	P501 : Dispose of contents/ container to an approved waste disposal plant. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P405 : Store locked up.

Related Laws:

RTECS#

MO6452000

Transport Information:

Customs Control Conditions (Q)

Applications & Literature plus

Application

Pregabalin: A Potent Ligand for the α2δ Subunit of Voltage-Gated Ca²⁺ Channels in the Central Nervous System

Pregabalin is one of the analogs of γ-aminobutyric acid (GABA) [A0282], but it works as a potent ligand for the α₂δ subunit of voltage-gated Ca²⁺ channels in the central nervous system that exhibits potent anxiolytic, analgesic, and anticonvulsant properties in a range of animal models. Pregabalin binds potently and selectively to the α₂δ subunit of "hyper-excited" voltage-gated calcium channels (VGCCs). The binding of pregabalin to VGCCs changes their conformation, reducing Ca²⁺ influx at nerve terminals. Consequently, pregabalin modulates the release of excitatory neurotransmitters in "hyper-excited" neurons, restoring them to normal physiological state. This mechanism of action is believed to confer on pregabalin its anxiolytic, analgesic, and anticonvulsant properties. (The product is for research purpose only.)

References

Identification of the α -δ-1 unit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin
- M. J. Field, P. J. Cox, E. Stott, H. Melrose, J. Offord, T.-Z. Su, S. Bramwell, L. Corradini, S. England, J. Winks, R. A. Kinloch, J. Hendrich, A. C. Dolphin, T. Webb, D. Williams, Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 17537.
Pharmacology and mechanism of action of pregabalin: The calcium channel α₂-δ (alpha₂-delta) subunit as a target for antiepileptic drug discovery (a review)
- C. P. Taylor, T. Angelotti, E. Fauman, Epilepsy Res. 2007, 73, 137.
Pregabalin: From molecule to medicine (a review)
- R. Kavoussi, Eur. Neuropsychopharmacol. 2006, 16, S128.
Simultaneous high-performance liquid chromatographic analysis of pregabalin, gabapentin and vigabatrin in human serum by precolumn derivatization with o-phtaldialdehyde and fluorescence detection
- T. A. C. Vermeij, P. M. Edelbroek, J. Chromatogr. B 2004, 810, 297.

Product Documents (Note: Some products will not have analytical charts available.)

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Product Number	P2840
Purity / Analysis Method	>98.0%(T)
Molecular Formula / Molecular Weight	C__8H__1__7NO__2 = 159.23
Physical State (20 deg.C)	Solid
Storage Temperature	Room Temperature (Recommended in a cool and dark place, <15°C)
CAS RN	148553-50-8
Reaxys Registry Number	8404778
PubChem Substance ID	468592747
MDL Number	MFCD00917044

CAS RN: 148553-50-8 | Product Number: P2840

Pregabalin

References

Safety Data Sheet (SDS)

Specifications

C of A & Other Certificates

Sample C of A

Analytical Charts

Other Documents

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