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CAS RN: 155148-31-5 | Product Number: P2620
AMD-3100 Octahydrochloride
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Purity: >98.0%(HPLC)
Synonyms:
- Plerixafor Octahydrochloride
- JM-3100
- SID-791
- 1,4-Bis[(1,4,8,11-tetraazacyclotetradecan-1-yl)methyl]benzene Octahydrochloride
- 1,1'-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane Octahydrochloride
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 25MG |
¥240.00
|
2 | Contact Us | 6 |
| 100MG |
¥960.00
|
1 | Contact Us | 16 |
* For order or inquiry, please contact
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| Product Number | P2620 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__8H__5__4N__8·8HCl = 794.46 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 155148-31-5 |
| Reaxys Registry Number | 8182245 |
| PubChem Substance ID | 468592637 |
| MDL Number | MFCD04974488 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Precipitation Titration) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 245 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | XA5255300 |
Transport Information:
| Customs Control Conditions (Q) |
Application
AMD-3100 Octahydrochloride: A CXC Chemokine Receptor Type 4 (CXCR4) Antagonist
AMD-3100 octahydrochloride (plerixafor octahydrochloride) is an antagonist of CXC chemokine receptor type 4 (CXCR4), which is a chemokine receptor expressed on immune cells and cancer cells. CXCR4 antagonists, including AMD-3100, were initially developed for the treatment of HIV-1 (AIDS), where CXCR4 functions as a co-receptor for virus entry into T cells.1) Subsequently, CXCR4 antagonists were noticed to induce leukocytosis, and are currently used for mobilization of hematopoietic stem cells.2,3) Recently, it has been reported that CXCR4 induces migration of cancer cells and is important for processes such as metastasis.3,4) Therefore, CXCR4 antagonists are expected to regulate these tumor metastatic processes. (The product is for research purpose only.)
References
- 1) AMD3100, a small molecule inhibitor of HIV-1 entry via the CXC4 co-receptor
- 2) Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist
- 3) CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers (a review)
- 4) CXCR4 in breast cancer: oncogenic role and therapeutic targeting
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Specifications
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